SYNTHESISE
We find and build every comparison the external evidence can support.
The comparative evidence you need already exists, published in the peer-reviewed literature or held in real-world data sources.
The challenge is building a comparator from this evidence that reflects the exact patients, treatment and outcome the drug is being judged on.
This usually takes 11 months[1]. We do it in weeks.
Our methods
Comparison feasibility
We map every comparison that can be built from the published literature and real-world data, finding those that reflect the exact patients, treatment and outcome the drug is being judged on. The output tells you which comparisons will stand up to HTA and payer scrutiny and which will not.
Pairwise comparative meta-analysis
We pool the published evidence and compare two drugs against each other. The analysis tells you which drug is more effective.
Benchmark meta-analysis
We pool the published evidence and provide a benchmark outcome, such as median overall survival in months, for multiple drugs. The analysis positions drugs against each other.
Network meta-analysis
We build a connected network of trials and estimate relative effects of multiple drugs. This analysis provides a ranking of likely effectiveness across the drugs, from best to worst.
Natural history characterisation
We synthesise evidence on disease progression, outcomes and standard of care. This contextualises efficacy and safety signals, and supports clinical development, orphan drug designation, breakthrough therapy and PRIME applications.
How we do it
We run evidence synthesis through Evidax TRACE™, our AI-augmented, human-in-the-loop workflow, purpose-built for drug development.
A senior methodologist leads every review. They set the protocol, decide which evidence is relevant, and are accountable for every decision.
TRACE provides the methodologist with AI assistance inside a purpose-built workflow, accelerating timelines and improving accuracy.
Every decision has a complete audit trail, and you see all of it on the Evidax Workspace.
References
- Cochrane Handbook for Systematic Reviews of Interventions v5.1.0 (2011). https://handbook-5-1.cochrane.org/